Technical Comments

Comment on “Local impermeant anions establish the neuronal chloride concentration”

Science  05 Sep 2014:
Vol. 345, Issue 6201, pp. 1130
DOI: 10.1126/science.1255337

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Glykys et al. (Reports, 7 February 2014, p. 670) proposed that cytoplasmic impermeant anions and polyanionic extracellular matrix glycoproteins establish the local neuronal intracellular chloride concentration, [Cl]i, and thereby the polarity of γ-aminobutyric acid type A (GABAA) receptor signaling. The experimental procedures and results in this study are insufficient to support these conclusions. Contradictory results previously published by these authors and other laboratories are not referred to.

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