Cell Biology

A long noncoding RNA helps cells divide

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Science  05 Sep 2014:
Vol. 345, Issue 6201, pp. 1132
DOI: 10.1126/science.345.6201.1132-a

Centromeres help chromosomes segregate

PHOTO: SPL/SCIENCE SOURCE

When cells divide, they distribute chromosomes to the daughter cells. Centromeres—specialized regions of chromosomes—ensure that the chromosomes segregate properly during the process. Quénet and Dalal find that an RNA transcribed from human centromeric DNA recruits proteins that form this specialized region. Unlike many RNAs, the centromeric RNA does not encode a protein, but instead binds to two proteins, CENP-A and HJURP, that help “package” DNA and proteins together so that the centromere can function properly.

eLife 10.7554/eLife.03254 (2014).

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