DRUG DELIVERY

A complementary refill? Yes, please!

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Science  12 Sep 2014:
Vol. 345, Issue 6202, pp. 1307-1308
DOI: 10.1126/science.345.6202.1307-g

Drugs delivered throughout the body often cause collateral damage to healthy tissues. When disease or injury is localized, patients can avoid this problem by using a drugdelivery device implanted in the target tissue. However, such devices eventually run out of drugs and must be removed surgically and refilled. Brudno et al. designed a drug-delivery device that can be refilled noninvasively and tested it in a mouse tumor model. They made the device from a gel tethered to short DNA sequences. To refill it, they coupled gel strands to drugs and tethered them to complementary DNA sequences, then injected the strands intravenously into the mice. Because of the complementary DNA sequences, the strands homed directly to the device.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1413027111 (2014).

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