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Science  19 Sep 2014:
Vol. 345, Issue 6203, pp. 1522
DOI: 10.1126/science.345.6203.1522-a

Quadrupole ToF MS System

The Xevo G2-XS mass spectrometer is a new high-performance benchtop quadrupole time-of-flight (QTof) mass spectrometer. Featuring the new XS Collision Cell, the Xevo G2-XS QTof stands alone among its peers in offering uncompromised analytical sensitivity and selectivity in a benchtop QTof mass spectrometer. The Xevo G2-XS QTof mass spectrometer combines the new XS Collision Cell with the proven, signature technologies of Tof-MRM, StepWave, and QuanTof to deliver optimum levels of robust sensitivity and selectivity, resulting in the detection of more low-level compounds than ever before. For targeted quantitative experiments, Tof-MRM mode delivers a 10-fold improvement in signal-to-noise when compared with full scan mode, resulting in limits of detection and quantification that completely redefine expectations for a benchtop high-resolution mass spectrometer. Another feature of the Xevo G2-XS QTof is the Waters mass spectrometry technology, a patented method of data acquisition that comprehensively catalogs complex samples in a single analysis.


Benzo(a)pyrene (BP) is a widespread environmental pollutant. A highly reactive diol epoxide derivative of BP, BPDE-I, is the major electrophilic, mutagenic, and carcinogenic metabolite of BP which is covalently bonded to the DNA and protein. The formed BPDE adduct, which is a biomarker of the body's metabolic response to exposure, is associated with increased risk of lung and breast cancer. BPDE is also a frequently used biomarker of oxidative DNA damage and oxidative stress. To address this need Trevigen offers a validated HT BPDE competitive enzyme-linked immunosorbent assay (ELISA) kit (4360-096-K), a fast and sensitive (5 nM BPDE-HSA) immunoassay for the detection and quantitation of BPDE adduct in plasma, serum, and cell culture supernatant samples. This assay employs a pre-coated BPDE-HSA monoclonal antibody, a labeled Biotinylated BPDE-HSA, a Strep-HRP conjugate, and chemiluminescent detection substrate to construct a high throughput assay flexible for your experimental design.

Compact Mass Spectrometer

An affordable high-performance liquid chromatography (LC) system is available to complement Advion's line of expression compact mass spectrometers (CMS). Leveraging the 100240 VAC requirements, the LC/CMS system can become transportable on a cart or installed in space-restricted benches and hoods, allowing for easy access. With unrivaled ease-of-use, and the ability to utilize the CMS for multi-modalities, Advion's LC/CMS offers chemists within teaching labs, research facilities, and industry a high-performance solution at an affordable price. LC/MS is an important technique for complex sample analysis, especially final synthetic route steps, registration vial characterization, and publication-quality data, while offering a level of high purification certainty. Integration of the system through the Clarity software program with full quantitation and 21CFR11 compliance makes it a complete LC solution.

Quantitative Proteomics Platform

The TripleTOF 6600 system with SWATH Acquisition 2.0 is the company's revolutionary solution for quantitative proteomics. This high-resolution, accurate-mass system, combined with the new SWATH Acquisition 2.0, brings new power to proteomic data challenges for advanced biomarker discovery and systems biology. As the emphasis in proteomics research shifts from cataloguing to comprehensive quantitation, the system enables the quantification of thousands of proteins across large sample sets with a level of data completeness and quantitative accuracy and precision that have only been achievable by "gold-standard," targeted MRM in the past. The TripleTOF 6600 system with SWATH 2.0 truly transforms proteomics research by providing an advanced level of data completeness and quantitative accuracy. Now, with the increased dynamic range of the TripleTOF 6600 System, researchers can more deeply interrogate complex samples. Combined with innovative variable window acquisition and the SWATH 2.0 processing software, a significant improvement in quantitative results has been realized.

High-Content Screening Microplates

CellCarrier Ultra 384-well microplates are designed specifically for high-content screening (HCS). The improved plate design results in higher quality image data and more robust results from HCS applications. The CellCarrier Ultra 384-well microplates are designed for enhanced performance in high-content imaging applications where the imaging surface is critical for generating high-resolution images and quality data. The plates are black and precisely engineered to have an extremely flat surface for efficient imaging. They are made using cyclic olefin, a plastic that has glass-like optical properties, to provide a clearer image. Additional features of the microplates include better well access when using water immersion, high numerical aperture objectives with an ultralow plate bottom, an improved lid design that reduces evaporation, corner spacers that avoid damaging the imaging surface when stacking, and a choice of different coatings to suit specific applications.

UltraFAIMS Platform

The UltraFAIMS series of products have been developed to enhance mass spectrometry by quickly simplifying complex mass spectra, separating isobaric ions, and reducing background. UltraFAIMS is a miniaturized chip-based FAIMS (Field Asymmetric Ion Mobility Spectrometry) platform technology that can be interfaced with mass spectrometers to provide an additional in-source separation stage for isobaric analytes, protein and peptide charge states, large and small proteins, isomers, and conformers. Miniaturizing the chip has allowed the generation of much higher field strengths than have been available in previous FAIMS systems. This means that a greater range of analytes can be separated, at faster speeds, without compromising the system sensitivity. The newly launched UltraFAIMS ion filters incorporate the miniaturized FAIMS chip, and can be retrofitted onto mass spectrometers. The low-cost modules have been shown to improve mass accuracy and detection limits, increase the level of quantitation and dynamic range, reduce background, and provide additional real-time separation within LC peaks.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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