Science Webinar Series

Culturing human cells: Optimizing growth conditions for immunotherapy

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Science  26 Sep 2014:
Vol. 345, Issue 6204, pp. 1638
DOI: 10.1126/science.345.6204.1638-c

Summary

Growing human cells in culture for research is one thing, but the isolation and culture of high-quality cells that will be re-injected back into the donor is quite another. Manipulation and expansion of cells in a clinical setting carries its own unique requirements and complications. Growth and survival needs to be optimized and quality control is paramount. Often only a single opportunity for successful treatment is possible, so chances of success need to be maximized in all respects, including high-yield isolation of good quality cells from patients, cell culture conditions, cell characterization, and reperfusion back into patients. During this webinar, we will broadly examine the process of immunotherapy as well as examine in more detail some of the most critical steps along the pathway to generating a therapeutic dose of modified cells.