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Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18

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Science  14 Nov 2014:
Vol. 346, Issue 6211, pp. 861-865
DOI: 10.1126/science.1256999

Article Information

vol. 346 no. 6211 861-865

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 4, 2014
  • Accepted for publication October 16, 2014

Author Information

  1. Benyue Zhang1,
  2. Benoit Chassaing1,
  3. Zhenda Shi1,
  4. Robin Uchiyama1,2,
  5. Zhan Zhang1,
  6. Timothy L. Denning1,2,
  7. Sue E. Crawford3,
  8. Andrea J. Pruijssers4,
  9. Jason A. Iskarpatyoti4,
  10. Mary K. Estes3,
  11. Terence S. Dermody4,5,
  12. Wenjun Ouyang6,
  13. Ifor R. Williams2,
  14. Matam Vijay-Kumar7,
  15. Andrew T. Gewirtz1,2,*
  1. 1Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
  2. 2Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
  3. 3Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
  4. 4Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
  5. 5Departments of Pediatrics, Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
  6. 6Department of Immunology, Genentech, South San Francisco, CA, USA.
  7. 7Department of Nutritional Sciences and Medicine, Pennsylvania State University, University Park, PA 16802, USA.
  1. *Corresponding Author. E-mail: agewirtz{at}gsu.edu

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