PerspectiveCircadian Rhythms

Temporal targets of drug action

See allHide authors and affiliations

Science  21 Nov 2014:
Vol. 346, Issue 6212, pp. 921-922
DOI: 10.1126/science.aaa2285

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


It has long been known that certain drug targets and many drug-metabolizing enzymes and cellular transporters are subject to variation in their abundance and activity during roughly 24-hour cycles. Indeed, variability in drug exposure and disposition following drug administration at different times of day has been appreciated for more than 40 years (1). However, this has had little impact on clinical practice, aside from some influence on cancer chemotherapy (2). A recent study by Zhang et al. (3) serves as a valuable corrective.