PerspectiveCircadian Rhythms

Temporal targets of drug action

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Science  21 Nov 2014:
Vol. 346, Issue 6212, pp. 921-922
DOI: 10.1126/science.aaa2285

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It has long been known that certain drug targets and many drug-metabolizing enzymes and cellular transporters are subject to variation in their abundance and activity during roughly 24-hour cycles. Indeed, variability in drug exposure and disposition following drug administration at different times of day has been appreciated for more than 40 years (1). However, this has had little impact on clinical practice, aside from some influence on cancer chemotherapy (2). A recent study by Zhang et al. (3) serves as a valuable corrective.