PerspectiveCell Biology

Powering the cell cycle

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Science  28 Nov 2014:
Vol. 346, Issue 6213, pp. 1059-1060
DOI: 10.1126/science.aaa2313

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To live means to grow, respond, reproduce, and adapt. All these processes require energy, which in most eukaryotic cells is provided by mitochondrial oxidative phosphorylation. Moreover, mitochondria have been implicated in other vital cellular processes, including programmed cell death (apoptosis) and calcium signaling. Hence, mitochondrial functions have to be tightly integrated into the cellular context, and the mechanisms that participate in this coordination are only just beginning to be understood. On page 1109 of this issue, Harbauer et al. (1) identify a link between the cell division cycle and mitochondrial protein transport as a driver of this process.