Science Webinar Series

Untangling the tumor microenvironment:
Illuminating the complex interactions and functions of immune cells

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Science  05 Dec 2014:
Vol. 346, Issue 6214, pp. 1247
DOI: 10.1126/science.346.6214.1247-c

Summary

Certain antibody therapies have demonstrated the potential for directing a patient's own immune system against tumors. Further advances in this area will depend upon a detailed understanding of the tumor microenvironment and characterization of the location and status of immune cells and their interaction with tumor cells. This will require methods that provide phenotyping of immune and cancer cells combined with information about their spatial relationship in tumor regions. Additionally, a deeper understanding of the signaling cascades active in immune recognition of cancers is crucial. During this webinar, we will discuss the bringing together of multiplexed fluorescent immunohistochemistry, advanced microscopy techniques, and bioinformatics, and how these are now enabling new insights into cancer biology and immunology.