In DepthThe Ebola Epidemic

High hopes for Guinean vaccine trial

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Science  16 Jan 2015:
Vol. 347, Issue 6219, pp. 219-220
DOI: 10.1126/science.347.6219.219

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Summary

The push to test Ebola vaccines in the field is accelerating. Two candidates may go into phase III trials in a matter of weeks; a third one has just entered a phase I trial. Researchers have designed very different phase III studies for Liberia, Sierra Leone, and Guinea, the three countries with ongoing virus transmission. One problem they're facing is that the number of new cases has dropped sharply in Liberia and is beginning to ebb in Sierra Leone. That's why many scientists say Guinea—where researchers plan to try a highly unusual ring vaccination design—is the most promising testing ground.

  • * With reporting by Kai Kupferschmidt and Jon Cohen.