HIV Eradication

A cure from which there is no escape

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Science  23 Jan 2015:
Vol. 347, Issue 6220, pp. 385-386
DOI: 10.1126/science.347.6220.385-g

One way to cure HIV-1 would be to pharmacologically drive virus production in latently infected cells and then to get CD8+ T cells to kill these virus-spewing cells. But HIV-1 mutates to escape CD8+ T cell responses, so is this strategy even possible? To find out, Deng et al. tested whether people chronically infected with HIV-1 harbor CD8+ T cells that can recognize unmutated portions of latent HIV-1. They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV-1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

Nature 10.1038/nature14053 (2015).

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