PerspectiveMicroscopy

The superresolved brain

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Science  30 Jan 2015:
Vol. 347, Issue 6221, pp. 474-475
DOI: 10.1126/science.aaa5084

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Summary

In the past decade, important advances have been made to increase the resolution of the light microscope, as acknowledged by last year's Nobel Prize for superresolved fluorescence microscopy (1, 2). This progress is fascinating but comes at the price of high illumination intensities or long recording times, and expensive instruments. As reported on page 543 of this issue, Chen et al. (3) have cleverly turned the problem around by asking: What if we leave the microscope as it is, and increase the object instead?