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Science  13 Feb 2015:
Vol. 347, Issue 6223, pp. 791
DOI: 10.1126/science.347.6223.791-a

qTOF Mass Spectrometers

The maXis line of ultrahigh resolution quadrupole time-of-flight (UHR-qTOF) mass spectrometers brings industry-leading resolution and mass accuracy to the liquid chromatography, time-of-flight MS market space. The system is designed to deliver outstanding resolution and mass accuracy that, for example, allows for unambiguous identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies. In addition, this level of performance also provides scientists confident detection and identification of modifications hard to detect at the protein level, such as deamidation. The maXis II system delivers the fastest time-to-success for life science researchers and across a broad range of applications from the in-depth identification and characterization of biopharmaceuticals and small molecule pharmaceuticals to bottom-up proteomics and proteoform screening.

High Throughput Lipid Analysis

A novel high throughput Shotgun Lipidomics technology has been designed based on the Hamilton STARlet platform in combination with a mass spectrometer and the proprietary software, LipotypeXplorer. The platform allows comprehensive and absolute quantitative lipidomics analysis from different types of up to 96 clinical or biological samples in three hours. The system is designed in a way that allows an easy adaption to various extraction procedures. All kinds of organic solvents for the lipid extraction can be handled in a reliable way using Hamilton's Anti Droplet Control technology. All liquid transfer steps are checked for accuracy and reproducibility using a balance to determine the real pipetted volume. The complete method validation included extraction of 90 copies of the same sample arrayed together on a single plate. Three independently prepared replicates of such plates were independently processed and analyzed on three consecutive days to check intraday and interday variation.

Metabolomics/Lipidomics Analyses Software

Progenesis QI Version 2.0 is the next generation of liquid chromatography-mass spectrometry (LC-MS) software for small molecule 'omics data analysis. This software complements the earlier introduction of Progenesis QI for proteomics Version 2.0 for large molecule 'omics data analysis. Both Progenesis QI and Progenesis QI for proteomics software take LC-MS data analysis to new levels of speed and sophistication, enabling users to rapidly quantify and identify the significantly changing small molecule, lipid compounds, and proteins in samples. The new features of Progenesis QI Version 2.0 include Pathway Mapping, which facilitates the process of placing discoveries into a biological context, extracting maximum value from 'omics data; workflow automation, which enables the software to move through multiple processing stages without user intervention; improved access to compound databases; and seamless integration with the extended statistics functionality in EZInfo 3.0, with two-way dataflow to allow for flexible data mining through a single, menu-driven command.

Glycan Quantitation Analysis

Enterprise Edition of SimGlycan v. 5.0 is a comprehensive high throughput tool that provides support for glycan quantitation using Thermo Scientific aminoxy-TMT for MS/MS glycan data analysis workflows. Additionally, it can be used for processing of liquid chromatography/mass spectrometry (LC-MS) data for peak detection, peak picking, and alignment of glycans based on retention time, precursor m/z values, and observed intensities across multiple samples. The Thermo Scientific aminoxyTMT reagents are designed to provide efficient relative quantitation of carbohydrates, improve labeled-glycan ionization efficiency, and increase analytical throughput. These reagents can be used for quantitative analysis of native N-glycans by direct or LC-coupled ESI-MS. Using SimGlycan, glycans are quantified by measuring reporter ion peak intensities from the corresponding MS/MS spectra. Various charts are provided to facilitate visualization of either the quantity of each glycan in different TMT channels or relative change in abundance of glycans across samples.

Lipid Analysis Software

Complementing Protein Metrics' advanced Byonic protein identification engine, Lipify software makes structural identifications across an expanding list of lipids (>20,000), covering many lipid subclasses, to provide automated processing of high throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) data. Lipify provides structural characterization as part of the identification process. This unique tool can even characterize lipids that have never been observed before, opening the door to new biological and medical discoveries. The Lipify software offers a friendly graphical user interface to allow scientists to interact with results and provide intuitive views of analyzed data that aids manual verification of identifications. Its algorithms are sensitive and efficient, with a typical search of 26,000 lipid targets completed in less than 15 seconds. Results can be readily exported for reporting and publication.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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