What are the genomic requirements for life?

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Science  20 Feb 2015:
Vol. 347, Issue 6224, pp. 837
DOI: 10.1126/science.347.6224.837-c

To promote identification and understanding of the minimal set of genomic elements required for life, Lluch-Senar et al. studied M. pneumonia. This small bacterium has an 816-kb genome with about 700 open reading frames; about a third of the genome appeared to be essential. Small open reading frames, of less than 100 residues, made up slightly more than half of the essential components, and they appeared to encode components of larger protein, DNA, or RNA complexes. Protein domains, rather than complete proteins, were often the essential elements of larger proteins, whereas regulatory elements—5′ untranslated regions and noncoding RNAs—were also fundamental components.

Mol. Syst. Biol. 10.15252/msb.20145558 (2015).

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