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m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

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Science  27 Feb 2015:
Vol. 347, Issue 6225, pp. 1002-1006
DOI: 10.1126/science.1261417

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mRNA modification regulates pluripotency

When stem cells progress from an embryonic pluripotent state toward a particular lineage, molecular switches dismantle the transcription factor network that keeps the cell pluripotent. Geula et al. now show that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition. Methylation destabilized mRNA transcripts and limited their translation efficiency, which promoted the timely decay of naïve pluripotency. This m6A methylation was also critical for mammalian development.

Science, this issue p. 1002