PerspectiveVirology

Delineating Ebola entry

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Science  27 Feb 2015:
Vol. 347, Issue 6225, pp. 947-948
DOI: 10.1126/science.aaa8121

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Summary

The means by which Ebola virus enters a cell are becoming less mysterious. Although a definitive cell surface receptor for the virus, if there is one, remains to be identified, the mechanism of gaining entry is beginning to be fleshed out. Once inside the cell, the importance of numerous sequential processes is becoming better understood. On page 995 of this issue, Sakurai et al. (1) add another element to the viral entry pathway by showing that a calcium channel called two-pore channel 2 (TPC2) is required for release of the viral genome into the host cell.