PROTEOMICS

The secrets of blood proteins revealed

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Science  27 Feb 2015:
Vol. 347, Issue 6225, pp. 961
DOI: 10.1126/science.347.6225.961-e

The levels of particular proteins in your blood can provide important insight into your health. However, to what degree environmental factors versus heritability influence the relative abundance of all blood proteins is unknown. To find out, Liu et al. used mass spectrometry on plasma samples collected from monozygotic and dizygotic twins at two different times. They detected 342 unique proteins overall, and although 80 showed evidence of heritability, they found that the expression of many proteins varied widely. Proteins used as clinical biomarkers showed less variability in expression overall; however, some were still quite variable, suggesting that scientists still need to better characterize the predictive value of these blood biomarkers.

Mol. Syst. Biol. 11, 786 (2015).

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