Eye Development

Eye development from both sides

See allHide authors and affiliations

Science  06 Mar 2015:
Vol. 347, Issue 6226, pp. 1110
DOI: 10.1126/science.347.6226.1110-b

In vertebrates, eye development begins with the outgrowth of the optic vesicle from the brain. The optic vesicle then transforms into a bilayered structure called the optic cup after extensive morphological movements, which scientists do not completely understand. In order to visualize these events, Heermann et al. used four-dimensional in vivo microscopy to track the movements of cells in the eyes of developing zebrafish. They found that cells from both sides of the optic vesicle generate the neuroretinal layer of the optic cup, rather than just the side that faces the lens as previously thought. The growth factor bone morphogenic protein facilitated this process.

eLife 4, e05216 (2015).

Navigate This Article