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Science  06 Mar 2015:
Vol. 347, Issue 6226, pp. 1160
DOI: 10.1126/science.347.6226.1160-a

Dry Reagent Cocktails

DuraClone IM premixed dry reagent cocktails standardize and streamline workflow for high-content flow cytometry in translational research studies involving identification of cellular subpopulations of the human immune system. These optimized, easy-to-use panels provide worry-free compensation to minimize labor and reduce variability and errors when characterizing alterations of immune status through detection of human blood-cell subpopulations. Dried down using a proprietary process that ensures high structural stability, DuraClone IM panels are stable for up to one year at room temperature. Simple, single-step resuspension of DuraClone cocktails by the addition of a cell suspension or whole blood minimizes variability, allowing generation of comparable data across geographies and institutions. DuraClone IM panels comprising basic phenotype, B cells, T cell subsets and dendritic cells are offered for "Research Use Only" in 25-test packages containing three complete compensation kits with a single-color set of compensation reagents specific for each panel.

Full-Height Liquid Handling Pump

The new Hamilton Precision Syringe Drive 6 (PSD/6) is a compact, full-height pump for precision dispensing of small to large volumes. The PSD/6 performs all standard liquid handling functions including dispensing, serial dispensing, and diluting and offers the largest range of compatible syringes sizes. Enhanced flow stability and increased dispense times make it ideal for applications like flow cytometry and microfluidics. Designed for simple integration, a variety of mounting configurations are possible for a single unit or a daisy chain of up to 16 pumps. With selectable communication protocols and flexible programming options, every detail of the pump's performance can be adjusted to accommodate even the most challenging applications. The PSD/6 syringe and valve drive movements are optimized to extend the life and time between product maintenance. By manufacturing all the fluid path components in house, Hamilton can ensure the fluid sub-system will provide superior performance, even in harsh conditions or under heavy duty cycles.

Patient-Derived Xenograft Models

The collection of Patient-Derived Xenograft (PDX) models of breast cancer allows the study of human tumors in an in vivo model system. PDX models are a key tool in the development of personalized medicines. The lines accurately model real patient tumors, enabling researchers to discover important genetic differences, develop biomarkers to distinguish them, and ultimately develop patient-specific therapies. The new collection includes 10 triple negative lines as well as several ER+ (estrogen receptor positive) lines. Whole genome sequencing has been performed on the originating tumors, early and late passages of PDX, as well as metastases, demonstrating striking similarity and faithful modeling of the original tumor, with all contaminating mouse signal removed. Using SAGE Labs' PDXplorer, customers can access a wealth of data on the PDX models, including comprehensive patient histories, estradiol responsiveness, RNAseq profiles, DNA microarrays, and phosphoprotein profiles, and can handpick the models that best support their research.

Simplified Liquid Extraction Sorbent

Novum Simplified Liquid Extraction (SLE) is a novel, synthetic alternative to traditional diatomaceous earth SLE (also known as supported liquid extraction) products and a simplified approach to traditional liquid-liquid extraction (LLE). Extraction techniques used prior to liquid and gas chromatography can improve results and reduce wear and tear on the instrument. As the first of its kind, the synthetic Novum SLE sorbent can be used with the same procedure as traditional SLE sorbents while delivering improved lot-to-lot reproducibility. Because it is a lab-manufactured sorbent, supplies are readily available, compared to diatomaceous earth, which is a natural resource that must be mined. Novum SLE simplifies the liquid-liquid extraction process by eliminating manual steps and it reduces solvent consumption. SLE also delivers higher sample recovery than liquid-liquid extraction methods by eliminating analyte loss due to emulsions that can form at the interface of the two liquid phases.

Multichannel Peristaltic Pump

Maximizing available bench-top space is important for many laboratories and a new design of peristaltic pump which provides up to four fluidic channels in a single pump will help technicians to eliminate the clutter of multiple pumps. The Ismatec Reglo ICC (Independent Channel Control) peristaltic pump expands the power of laboratory and life-science pumping by providing individual control of each fluidic channel as well as allowing users to solve application complexity in a single pump. Most importantly, independent channel calibration minimizes the tube-to-tube differences and this results in optimum accuracy for a multichannel peristaltic pump. Easy-to-use tubing cassettes also provides for quick, convenient changeovers. The Reglo ICC pump is self-priming, not sensitive to dry-running and can handle flow rates from of 0.002 up to 35 mL/min and differential pressures up to 1 bar, while an easy-to-use USB interface means connections can be made quickly.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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