Science Webinar Series

Charting the human proteome: Understanding disease using a tissue-based atlas

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Science  13 Mar 2015:
Vol. 347, Issue 6227, pp. 1274
DOI: 10.1126/science.347.6227.1274-c


A decade on from the completion of the Human Genome, the Human Protein Atlas, a multinational research project supported by the non-profit Knut and Alice Wallenberg Foundation, recently launched (November 6, 2014) an open source tissue-based interactive map of the human proteome. A team of multidisciplinary researchers with expertise spanning biotechnology, information technology, and medicine have used a combination of several 'omics technologies to map proteins down to the single cell level, showing both proteins restricted to certain tissues—such as the brain, heart, or liver—and those present in all tissues. It has taken this team over 1,000 person years to compile a searchable, open source database ( comprising 13 million annotated images of human tissues. The interactive database is aimed at researchers interested in basic research into human biology as well as those working in translational medicine. In this webinar, three of the researchers involved in this program will provide their insights regarding the lessons learned from this intensive effort to map the human proteome.