Aging

DNA mutations do not age yeast

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Science  20 Mar 2015:
Vol. 347, Issue 6228, pp. 1326
DOI: 10.1126/science.347.6228.1326-d

The molecular basis of aging—just what it is that wears out and causes the functional decline of an aged cell or organism—remains unclear. In hope of better understanding this, Kaya et al. monitored individual yeast cells and sequenced their DNA to test whether accumulated DNA mutations are a cause of replicative aging in yeast. The number of daughter cells produced before a mother yeast cell dies defines the replicative life span of the mother cell. But the cells accumulated only 0.4 mutations over the life span of an average cell. Thus, at least in yeast, DNA mutations do not seem to cause aging.

Aging Cell 10.1111/acel.12290 (2015).

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