Infectious Disease

A virulence factor comes under scrutiny

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Science  20 Mar 2015:
Vol. 347, Issue 6228, pp. 1326
DOI: 10.1126/science.347.6228.1326-g

The human pathogen Streptococcus pyogenes produces streptolysin S (SLS), a virulence factor that helps the pathogen to invade host cells and to evade recognition by the host immune system. Maxson et al. show that the HIV protease inhibitor nelfinavir blocks a key step during SLS biosynthesis. The authors synthesize and test nelfinavir analogs to study the role of the SagE protein in the SLS biosynthesis pathway. Use of these analogs to inhibit SLS production will help to elucidate how SLS contributes to S. pyogenes virulence and may even lead to novel treatment strategies.

ACS Chem. Biol. 10.1021/cb500843r (2015)

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