CANCER BIOLOGY

A CRISPR view of tumor metastasis

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Science  27 Mar 2015:
Vol. 347, Issue 6229, pp. 1433
DOI: 10.1126/science.347.6229.1433-b

Large tumors metastasize more often than small tumors. Is this simply because large tumors release a greater number of malignant cells into the circulation? Or is it because the genetic changes in tumor cells that drive them to proliferate rapidly are the same as those that promote their metastatic behavior? To explore this question, Chen et al. designed a screen based on a genome-editing technology called CRISPR-Cas9 to identify genes that, when inactivated, enhance tumor growth, lung metastasis, or both in mice. The small set of inactivated genes found in metastatic lesions largely overlapped with the set found in late-stage primary tumors, implying that functional loss of these genes drives both growth and metastasis.

Cell 10.1016/j.cell.2015.02.038 (2015).

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