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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

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Science  03 Apr 2015:
Vol. 348, Issue 6230, pp. 124-128
DOI: 10.1126/science.aaa1348

Article Information

vol. 348 no. 6230 124-128

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History: 
  • Received for publication October 21, 2014
  • Accepted for publication February 27, 2015

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Author Information

  1. Naiyer A. Rizvi1,2,*,,
  2. Matthew D. Hellmann1,2,*,
  3. Alexandra Snyder1,2,3,*,
  4. Pia Kvistborg4,
  5. Vladimir Makarov3,
  6. Jonathan J. Havel3,
  7. William Lee5,
  8. Jianda Yuan6,
  9. Phillip Wong6,
  10. Teresa S. Ho6,
  11. Martin L. Miller7,
  12. Natasha Rekhtman8,
  13. Andre L. Moreira8,
  14. Fawzia Ibrahim1,
  15. Cameron Bruggeman9,
  16. Billel Gasmi10,
  17. Roberta Zappasodi10,
  18. Yuka Maeda10,
  19. Chris Sander7,
  20. Edward B. Garon11,
  21. Taha Merghoub1,10,
  22. Jedd D. Wolchok1,2,10,
  23. Ton N. Schumacher4,
  24. Timothy A. Chan2,3,5,
  1. 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Weill Cornell Medical College, New York, NY, 10065, USA.
  3. 3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  5. 5Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  6. 6Immune Monitoring Core, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Computation Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  9. 9Department of Mathematics, Columbia University, New York, NY, 10027, USA.
  10. 10Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  11. 11David Geffen School of Medicine at UCLA, 2825 Santa Monica Boulevard, Suite 200, Santa Monica, CA 90404, USA.
  1. Corresponding author. E-mail: chant{at}mskcc.org
  1. * These authors contributed equally to this work.

  • Present address: Division of Hematology/Oncology, New York-Presbyterian/Columbia University, New York, NY, USA.

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