Cell Biology

Keeping the cell nucleus pumped up

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Science  17 Apr 2015:
Vol. 348, Issue 6232, pp. 299
DOI: 10.1126/science.348.6232.299-e

The nucleus is the most prominent organelle inside eukaryotic cells. It is often roughly spherical in shape and houses the genomic DNA. Nuclear Lamins are important for maintaining nuclear shape, and deformed nuclei are often associated with premature aging diseases. Verboon et al. find that the fruit fly gene washout (wash), involved in maintaining endosome shape in the cytoplasm, is also required to maintain the smooth spherical shape of the nucleus. Wash protein interacts with Lamin and is associated with heterochromatin in the nucleus. It also helps organize chromosomes and subnuclear domains, such as the nucleolus and cajal bodies.

Curr. Biol. 25, 804 (2015).

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