Cell Differentiation

Differentiating blood stem cells

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Science  24 Apr 2015:
Vol. 348, Issue 6233, pp. 409
DOI: 10.1126/science.348.6233.409-e

Hematopoietic stem cells (HSCs), which generate all blood cell types, contain hundreds of long noncoding RNAs (lncRNAs). Luo et al. identify 159 lncRNAs that are likely to be HSC-specific (lncHSCs) through deep RNA sequencing of primitive long-term HSCs from mouse bone marrow. As HSC function decreases with age, lncHSCs show reduced expression. Furthermore, like HSC-specific protein genes, promoters of lncRNAs are bound specifically by HSC transcription factors for regulated expression. Analysis of two specific lncRNAs reveals a role for lncHSC-1 in myeloid differentiation and lncHSC-2 involvement in HSC self-renewal and T cell differentiation. Analysis of the many other HSC-specific lncRNAs is likely to reveal varied mechanisms in regulating the self-renewal and differentiation of blood types.

Cell Stem Cell 10.1016/j.stem.2015.02.002 (2015).

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