T Cells

T cells require mRNA modifications

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Science  01 May 2015:
Vol. 348, Issue 6234, pp. 537
DOI: 10.1126/science.348.6234.537-c

T cells are important components of our immune system that recognize and respond to immune threats. Stimulation of T cells results in up-regulation of the RNA binding protein CELF2 (CUGBP, Elav-like family member 2). This gene is associated with posttranscriptional modifications of RNAs, including alternative splicing. Mallory et al. show that in response to T cell stimulation, expression of CELF2 is up-regulated and its transcripts are stabilized, ensuring an increase in the availability of this RNA. Furthermore, this up-regulation of CELF2 is associated with specific alternative exon transcripts and isoform expression within stimulated T cells. These results suggest that regulation of specific transcriptomes is important for mounting an immune response.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1423695112 (2015).

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