King of the pills

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Science  08 May 2015:
Vol. 348, Issue 6235, pp. 622-625
DOI: 10.1126/science.348.6235.622

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Raymond Schinazi, an unusual academic/entrepreneur hybrid, has had his hand in the development of five lifesaving drugs that have come to market—and he's still going. An organic chemist based at Emory University in Atlanta who has helped start several biotech companies, Schinazi has made hundreds of millions of dollars from the drugs, which treat HIV and hepatitis B and help cure hepatitis C. He specializes in nucleoside and nucleotide analogs that trip up viruses, a strategy once dismissed by many drug developers as too dangerous. His accomplishments have won high praise from his admirers, but, inevitably enough, his remarkable success brought on a tangle of lawsuits, increased scrutiny, and a few fallouts with longtime collaborators. "When you're very successful," he says, "people are very jealous."