Chemistry

Water helpful but not needed to fold DNA

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Science  15 May 2015:
Vol. 348, Issue 6236, pp. 769
DOI: 10.1126/science.348.6236.769-e

DNA has found a range of applications in chemistry and materials science, from acting as a link that connects other materials to forming complex structures. DNA structures are formed in water and cannot be transferred to organic solvents without a loss of order or change in helical structure. Gállego et al. show that a deep eutectic solvent composed of a 4:1 mixture of glycerol and choline chloride enables DNA assembly under room-temperature conditions. When water was added to the mix to lower the viscosity, the assembly time was reduced from 6 days to 20 min, thus providing a method for kinetic control of the assembled structures.

Angew. Chem. Int. Ed. 10.1002/anie.201412354 (2015).

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