Systems Biology

Signaling at the heart of blood pressure regulation

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Science  15 May 2015:
Vol. 348, Issue 6236, pp. 769
DOI: 10.1126/science.348.6236.769-f

Genetic variants, detected in large genome-wide association studies (GWASs) of blood pressure regulation in humans, account for only about 1% of the variability observed between individuals. Thus, better understanding of complex regulatory networks is necessary to find causal events and potential therapeutic targets. Huan et al. used integrative analysis that included transcriptional profiling and coexpression network analysis, GWASs, and molecular network modeling to tease out “key driver” genes that are central to regulatory modules that control blood pressure. One of these was SH2B3, a cell signaling adaptor protein previously detected in GWAS studies. The analysis further suggested that SH2B3 may function by altering inflammatory responses and T cell functions.

Mol. Syst. Biol. 10.15252/msb.20145399 (2015).

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