Aging

In search fo an anti-aging drug

+ See all authors and affiliations

Science  05 Jun 2015:
Vol. 348, Issue 6239, pp. 1103
DOI: 10.1126/science.348.6239.1103-b

As organisms age, they accumulate cells that can no longer proliferate. Such cells— termed “senescent”—persist and appear to promote aging by producing and secreting a variety of proteins. Zhu et al. tested whether drugs that inhibit cellular signaling pathways that make senescent cells resistant to stress and cell death could deplete senescent cells in mice. A combination of two drugs that inhibit such pathways selectively killed senescent cells in vitro, improved heart and vascular function in aging mice, and improved symptoms in a mouse model of accelerated aging. Although pinpointing the relevant targets of these drugs is difficult, the studies indicate that selectively targeting senescent cells with small molecules may be feasible.

Aging Cell 10.1111/acel.12344 (2015).

Navigate This Article