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Science  05 Jun 2015:
Vol. 348, Issue 6239, pp. 1164
DOI: 10.1126/science.348.6239.1164-a

Hotplate Stirrers

Hotplate stirrers are designed to offer synthetic chemistry laboratories affordability, top-build quality, and high performance without compromising on safety. Manufactured in an ISO9001-2008 production facility, each hotplate stirrer incorporates two independent control circuits. The additional and independent safety circuit is for limiting the maximum heating plate temperature; this can be adjusted between 50°and 360°but cannot be changed accidentally. This ensures that the flashpoint of your reaction solvent is not exceeded, making it ideal for teaching laboratories. A hermetically sealed design protects the hotplate stirrer motor assembly from spillages ensuring long-term reliability and operator safety. For labs looking to regularly undertake unattended overnight reactions, Asynt hotplate stirrer packages are supplied with an additional third temperature controller, which improves reproducibility and accuracy to within 0.5°while maintaining operational safety. The hotplate stirrers also feature a very powerful magnetic drive with ramp start function, especially useful when stirring more viscous samples or for parallel synthesis of multiple tubes or flasks.

Methotrexate ELISA Kit

Methotrexate is a drug designed as an anti-folate to inhibit the metabolism of folic acid. The methotrexate enzyme-linked immunosorbent assay (ELISA) enables the monitoring of methotrexate levels during treatment of cancer and rheumatoid arthritis. The methotrexate assay is also appropriate for the detection of methotrexate contamination after its use as a selective agent for recombinant protein production in mammalian cell lines. The ultrasensitive assay allows for detection of as little as 1.4 ng/mL of methotrexate in human serum and plasma. It has also been validated for use in human urine, mouse plasma, mouse serum, rat plasma, and rat serum. The ELISA offers a broad dynamic range, reducing the need to dilute your samples. The kit allows for high throughput analysis and time-savings through the analysis of up to 38 samples in duplicate in just 90 minutes. The ELISA is thoroughly validated to ensure excellent reproducibility between experiments, and low cross-reactivity with structurally related molecules.

Multiphoton Laser Scanning Microscope

The FluoView FVMPE-RS series' high-speed scanner allows observation of ultrarapid biological responses, and the system can obtain vivid images from as deep as 8 mm below the tissue surface. Two new configurations now expand the FluoView FVMPE-RS series beyond the original upright frame version introduced in 2013 to offer even greater scope and flexibility for research. The new configurations also open up a wide range of observation possibilities suited to imaging a greater variety of biological specimens. The Gantry microscope frame features an ultrastable arch-like structure that allows considerable space beneath the objective to accommodate experiments of varied sizes. A volume of 640 mm wide, 355 mm high, and 520 mm deep is available if the stage is removed, providing sufficient space for the researcher's own experimental apparatus and providing flexibility to suit different observation purposes. The inverted microscope frame is ideal for observation of cells in three-dimensional cultures, where multiple layers of cells are cultured in a petri dish or similar vessel.

No-Wash Potassium Ion Channel Assay Kit

The new homogeneous, no-wash assay is designed to measure ligand- and voltage-gated potassium channel activity. The FLIPR Potassium Assay Kit uses a novel thallium-sensitive indicator dye and a masking agent to significantly widen the conventional assay window, enabling studies of channels with low conductance or low expression levels. The kit's protocol eliminates the customary wash steps that introduce artificial variation and limit high throughput automation. Current thallium-based potassium ion channel assays require multiple buffer or media replacements, making them slow and cumbersome, and prone to well-to-well variation. Pervasive background noise also undermines accurate assessment of the small signals generated by many low-conductance channels or low-expressing cell lines. The FLIPR Potassium Assay Kit directly measures potassium channel function using a thallium-sensitive indicator dye that passively diffuses into cells as an acetoxymethyl ester. Cytoplasmic esterases cleave the dye into its fluorogenic form. A proprietary masking agent further reduces the background fluorescence and enhances the signal-to-noise ratio.

Mounting Media

The latest addition to the Vectashield Mounting Media product line is Vectashield HardSet with Phalloidin. This new formulation contains fluorescently labeled Phalloidin, that specifically binds actin filaments within a cell. The tetramethylrhodamine phalloidin in this product produces an orange-red fluorescent signal when excited at 544 nm and viewed at 572 nm. One or two drops are directly applied to the cell/tissue preparation similar to our other Vectashield products. Actin filament architecture can then be viewed along with a contrasting fluorescent marker for a specific target antigen. Vectashield Mounting Media are unsurpassed in preventing photobleaching of fluorescent proteins and fluorescent dyes (see website for compatibility).

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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