Correlated gene expression supports synchronous activity in brain networks

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Science  12 Jun 2015:
Vol. 348, Issue 6240, pp. 1241-1244
DOI: 10.1126/science.1255905
  • Fig. 1 Functional networks in MRI and gene expression data.

    (A) The four functional networks of interest. Red, dorsal default mode; yellow, salience; green, visuospatial; blue, sensorimotor. (B) AIBS brain samples assigned to their corresponding functional network. Solid circles are samples assigned to the four networks of interest, open circles show samples in the nine other networks, and dots show non-network AIBS samples.

  • Fig. 2 In vivo functional connectivity differences related to the consensus gene list.

    Difference in in vivo functional connectivity between the averages of the top 20 and the bottom 20 subjects in IMAGEN, ranked by genotype score with respect to the consensus list of genes. (A) Difference matrix sorted by functional network (correlation differences smaller than |0.05| are not shown). Positive values indicate connections that are stronger in high genotype score subjects, and negative values indicate the opposite. Connections are mostly increased within functional networks, but also between some functional networks. (B) MNI space sagittal view of within-network connections that are stronger in high-genotype-score subjects. Regions (disks) are coded according to the functional network they belong to: red, dorsal default mode; yellow, salience; green, visuospatial; blue, sensorimotor. Connections (lines) are color-coded to their functional networks. (C) Same, for connections that are stronger in low-genotype-score subjects. The majority of connections are strengthened in high-genotype-score subjects.

  • Fig. 3 Mouse mesoscale connectivity and transcriptional similarity.

    (A) Mouse isocortex parcellated into 38 regions (23). (B) Corresponding symmetrized, thresholded, and normalized ipsilateral axonal connectivity weights. (C) Transcriptional similarity (genetic correlation), using our consensus list of genes.

Supplementary Materials

  • Correlated gene expression supports synchronous activity in brain networks

    Jonas Richiardi, Andre Altmann, Anna-Clare Milazzo, Catie Chang, M. Mallar Chakravarty, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Mira Fauth-Bühler, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Hervé Lemaître, Karl F. Mann, Jean-Luc Martinot, Frauke Nees, Tomáš Paus, Zdenka Pausova, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Rainer Spanagel, Andreas Ströhle, Gunter Schumann, Mike Hawrylycz, Jean-Baptiste Poline, Michael D. Greicius, IMAGEN consortium

    Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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    • Materials and Methods
    • Supplementary Text
    • Figs. S1 to S5
    • Tables S1 to S10
    • IMAGEN consortium author list
    • Full Reference List
    Data File S1
    Data File S2
    Data File S3

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