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Small animal imaging: Data that's more than skin deep

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Science  12 Jun 2015:
Vol. 348, Issue 6240, pp. 1271-1273
DOI: 10.1126/science.348.6240.1271

Summary

To minimize complexity, researchers often study cellular proteins or nucleic acids in isolation. But sometimes—when testing a drug's efficacy and safety, for instance, or monitoring tumor progression—ex vivo just won't do. The only way to know how a compound or cells will behave in the body is to put them into an animal and watch what happens live. The results are easily recognizable in the pages of your favorite journal: the ghostly outline of a mouse, with a telltale multicolored heat bloom indicating where the action is.