Science Webinar Series

Sourcing niche cell populations: Techniques for isolating and characterizing progenitor cells

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Science  19 Jun 2015:
Vol. 348, Issue 6241, pp. 1383
DOI: 10.1126/science.348.6241.1383-c

Summary

Understanding stem/progenitor cells—which can develop into various types of tissue—are key to developing novel approaches for regenerative medicine. Techniques enabling the isolation of specific cell populations have advanced our ability to identify and characterize niche cell types which may be used to replace or engineer cells/tissue. The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue. In this webinar, we will hear from experts about different ways to isolate and characterize specific cell populations, including the nephrogenic progenitors that give rise to mature functional renal cells and mesenchymal stem cells which can differentiate into multiple cell types.