Cell Signaling

Protein kinase C shapes calcium signals

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Science  03 Jul 2015:
Vol. 349, Issue 6243, pp. 43
DOI: 10.1126/science.349.6243.43-e

The activation of hormone receptors on cells causes the concentration of free calcium in the cytoplasm to oscillate. Cells can encode information in the frequency, amplitude, and duration of such calcium oscillations, which may modulate the activation of downstream signaling pathways. Bartlett et al. compared calcium signals generated by hormone receptors or by a simpler mechanism that bypasses these receptors in rat hepatocytes, a type of liver cell. This allowed the authors to isolate the effects of the enzyme protein kinase C (PKC) on calcium oscillations, because PKC is only activated downstream of the receptor. PKC regulated both the shape and propagation rates of calcium waves

J. Biol. Chem. 10.1074/jbc.M115.657767 (2015).

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