Technical Comments

Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”

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Science  10 Jul 2015:
Vol. 349, Issue 6244, pp. 149
DOI: 10.1126/science.aaa9349

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Ma et al. (Reports, 10 October 2014, p. 219) report asymmetric syntheses of sceptrin and massadine and, through a stereochemical reassignment, claim to “uncover enantiodivergence as a new biosynthetic paradigm for natural products.” We challenge and clarify this claim with relevant examples from the literature of this well-known phenomenon of enantiodivergent congener biosynthesis within the same producing organism.

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