Paternal Chromatin

Biparental control in remodeling sperm

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Science  07 Aug 2015:
Vol. 349, Issue 6248, pp. 599
DOI: 10.1126/science.349.6248.599-b

Maternally and paternally inherited animal genomes reorganize and replicate before entering the first zygotic mitosis. Maternally deposited proteins in the egg recondition the sperm DNA; however, Levine et al. show that paternal factors are also involved. The Drosophila testis-specific protein HP1E localizes to paternal chromosomes and controls sperm DNA reorganization to prime it for embryonic chromosome segregation. Elimination of HP1E in males results in male sterility. Hence, proteins from both parents prime sperm DNA so it can be synchronized with the maternal genome for the first zygotic mitosis.

eLife 10.7554/eLife.07378 (2015).

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