Tumor angiogenesis, from foe to friend

See allHide authors and affiliations

Science  14 Aug 2015:
Vol. 349, Issue 6249, pp. 694-695
DOI: 10.1126/science.aad0862

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Targeting the tumor vasculature to “starve a tumor to death” instead of targeting tumor cells with chemotherapeutic drugs was conceived over four decades ago and has led to the development of antiangiogenic drugs approved for use against various human malignancies (1). So far, however, antiangiogenic therapy has not fulfilled expectations because it aids only a subset of cancer patients and provides only transitory improvements. Vascular-disrupting agents were developed to more rigorously deplete tumor vessels (2). However, this approach leads to hypoxia, which promotes neovascularization and tumor regrowth. The sobering realization is that the more we try to exterminate tumor vessels, the more aggressively tumors respond to impede these efforts, sometimes becoming more belligerent tumors. Is manipulating the vasculature to control tumor growth a promising strategy after all?