Heart Development

The way to a broken heart

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Science  14 Aug 2015:
Vol. 349, Issue 6249, pp. 702
DOI: 10.1126/science.349.6249.702-a

One cell division too many can compromise heart function

ILLUSTRATION: SCIENCE PICTURE CO/SCIENCE SOURCE

Mice lacking cardiac myosin binding protein C (MYBC) develop defective hearts that are twice the normal size. MYBC is a component of contractile thick filaments in the cardiac muscle. Jiang et al. found that the heart cells in mice lacking MYBC divided one extra time shortly after birth—when normal mouse heart cells would have stopped dividing. This caused the mice to have more myocytes with single nuclei—which compromise heart function. This unanticipated role of a structural protein in regulating how muscle cells divide may be important in different types of cardiomyopathy in human patients.

Proc. Natl. Acad. Sci. U.S.A. 112, 9046 (2015).

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