Technical Comments

Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase”

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Science  28 Aug 2015:
Vol. 349, Issue 6251, pp. 936
DOI: 10.1126/science.aab0095

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Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field–dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis.

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