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Greenlandic Inuit show genetic signatures of diet and climate adaptation
- Matteo Fumagalli1,2,*,
- Ida Moltke3,*,
- Niels Grarup4,
- Fernando Racimo2,
- Peter Bjerregaard5,6,
- Marit E. Jørgensen5,7,
- Thorfinn S. Korneliussen8,
- Pascale Gerbault1,9,
- Line Skotte3,
- Allan Linneberg10,11,12,
- Cramer Christensen13,
- Ivan Brandslund14,15,
- Torben Jørgensen10,16,17,
- Emilia Huerta-Sánchez18,
- Erik B. Schmidt17,19,
- Oluf Pedersen4,
- Torben Hansen4,†,
- Anders Albrechtsen3,†,
- Rasmus Nielsen2,20,†
- 1Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, UK.
- 2Department of Integrative Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
- 3The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
- 4The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
- 5National Institute of Public Health, University of Southern Denmark, 1353 Copenhagen, Denmark.
- 6Greenland Center for Health Research, University of Greenland, Nuuk, Greenland.
- 7Steno Diabetes Center, 2820 Gentofte, Denmark.
- 8Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.
- 9Department of Anthropology, University College London, London WC1H 0BW, UK.
- 10Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
- 11Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
- 12Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
- 13Department of Medicine, Lillebaelt Hospital, Vejle, Denmark.
- 14Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
- 15Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
- 16Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
- 17Faculty of Medicine, University of Aalborg, Aalborg, Denmark.
- 18School of Natural Sciences, University of California–Merced, Merced, CA 95343, USA.
- 19Department of Cardiology, Aalborg University Hospital, 9100 Aalborg, Denmark.
- 20Department of Statistics, University of California–Berkeley, Berkeley, CA 94720, USA.
- ↵†Corresponding author. E-mail: torben.hansen{at}sund.ku.dk (T.H.); albrecht{at}binf.ku.dk (A.A.); rasmus_nielsen{at}berkeley.edu (R.N.)
↵* These authors contributed equally to this work.
Science 18 Sep 2015:
Vol. 349, Issue 6254, pp. 1343-1347
DOI: 10.1126/science.aab2319
Vol. 349, Issue 6254, pp. 1343-1347
DOI: 10.1126/science.aab2319
Matteo Fumagalli
Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, UK.Department of Integrative Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
Ida Moltke
The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
Niels Grarup
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Fernando Racimo
Department of Integrative Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
Peter Bjerregaard
National Institute of Public Health, University of Southern Denmark, 1353 Copenhagen, Denmark.Greenland Center for Health Research, University of Greenland, Nuuk, Greenland.
Marit E. Jørgensen
National Institute of Public Health, University of Southern Denmark, 1353 Copenhagen, Denmark.Steno Diabetes Center, 2820 Gentofte, Denmark.
Thorfinn S. Korneliussen
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.
Pascale Gerbault
Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, UK.Department of Anthropology, University College London, London WC1H 0BW, UK.
Line Skotte
The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
Allan Linneberg
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cramer Christensen
Department of Medicine, Lillebaelt Hospital, Vejle, Denmark.
Ivan Brandslund
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Torben Jørgensen
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Faculty of Medicine, University of Aalborg, Aalborg, Denmark.
Emilia Huerta-Sánchez
School of Natural Sciences, University of California–Merced, Merced, CA 95343, USA.
Erik B. Schmidt
Faculty of Medicine, University of Aalborg, Aalborg, Denmark.Department of Cardiology, Aalborg University Hospital, 9100 Aalborg, Denmark.
Oluf Pedersen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Torben Hansen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Anders Albrechtsen
The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
Rasmus Nielsen
Department of Integrative Biology, University of California–Berkeley, Berkeley, CA 94720, USA.Department of Statistics, University of California–Berkeley, Berkeley, CA 94720, USA.
