DRUG DISCOVERY

A natural product map

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Science  09 Oct 2015:
Vol. 350, Issue 6257, pp. 174
DOI: 10.1126/science.350.6257.174-a

Active compounds in marine sediment bacteria revealed through rapid screen

PHOTO: ©LOGAN MOCK-BUNTING/CORBIS

Natural products are a rich source for drug development, but the complexity of extracts from natural products makes it difficult to identify specific biologically active components. Kurita et al. describe a platform that predicts the identities and biological activities of compounds in a natural marine sediment extract. Methods exist to characterize the activities of extracts by profiling their effects in cell-based assays, and mass spectroscopy approaches can complex extracts and distinguish significant components from noise. Kurita et al. combine these methods in a platform termed Compound Activity Mapping in which they interrogate a library of 234 extracts and identify 11 known compound families and four new compounds that cause endoplasmic reticulum stress.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1507743112 (2015).

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