RNA Processing

Tipping your RNA cap to stressful times

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Science  16 Oct 2015:
Vol. 350, Issue 6258, pp. 289
DOI: 10.1126/science.350.6258.289-b

RNAs transcribed by RNA polymerase II have a chemical “cap” added to their 5′ ends. The cap binding complex (CBC), which consists of the nuclear cap binding protein (NCBP) 1 and NCBP2, binds to the cap and ensures proper RNA processing and localization within the cell. Gebhardt et al. discovered a second, alternative CBC, which consists of NCBP1 and a previously poorly characterized but highly conserved protein, christened NCBP3. The two CBCs have both redundant and specific functions, with the alternative CBC seemingly being specifically critical for survival under stressful conditions, such as viral infection.

Nat. Comm. 6, 10.1038/ncomms9192 (2015).

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