CANCER

Disrupted signaling networks in cancer

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Science  16 Oct 2015:
Vol. 350, Issue 6258, pp. 289-290
DOI: 10.1126/science.350.6258.289-c

For personalized cancer therapy to succeed in the clinic, scientists need to identify and understand how genetic mutations in tumor cells can drive uncontrolled cell growth. In two studies, Creixell et al. present theoretical, computational, and experimental analysis of the mechanisms by which mutations might alter a cancer cell's biochemical regulatory networks. A computational approach helped define the molecular basis of substrate specificity of protein kinases, enzymes well known to contribute to certain forms of cancer. Such understanding can help define mutations that would cause signaling to go awry in cancer cells. Their results support the idea that besides modifications that activate or suppress normal signaling events, cancer cells may also accumulate mutations that actually rewire regulatory pathways.

Cell 163, 187; 202 (2015).

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