Visualizing trans-infection

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Science  30 Oct 2015:
Vol. 350, Issue 6260, pp. 511-512
DOI: 10.1126/science.aad5409

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A fuller understanding of how a virus establishes infection should help in developing approaches that minimize the associated pathology. On page 563 in this issue, Sewald et al. (1) succeed in visualizing interactions between retroviruses and cells within the immune tissues of live mice. This is exciting and notable for two reasons. It provides visual insights into the earliest steps leading to systemic infection in a living animal. Additionally, it demonstrates that multiple modes of infection can be used by a virus during dissemination. The observations described begin to reveal the complex steps that a virus must take to establish systemic infection.