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Science  30 Oct 2015:
Vol. 350, Issue 6260, pp. 572
DOI: 10.1126/science.350.6260.572-a

DNA Electrophoresis

The "Safe" Series of products has been designed to make DNA electrophoresis procedures safer, more convenient, and more economical to run. The series offers an alternative to traditional methods as it eliminates the need for ethidium bromide and ultraviolet light, without compromising the results of electrophoresis procedures. This is accomplished by combining the merits of three innovative products. runSAFE is a new and completely safe stain for DNA gel electrophoresis. runVIEW is an innovative new system that can be used to maximize the efficiency of DNA recovery from stained gels by minimizing the number of steps involved in postelectrophoretic purification. runVIEW uses a blue light-emitting diode (LED) gel illuminator that is inherently safe. runDOC is a benchtop gel documentation system that sits above the gel tank and enables multiple real-time images of the process to be taken. Combining these systems provides a safe, convenient, and easy-to-use integrated solution for DNA gel electrophoresis covering each stage of the process.

Glycoprotein Column

The new ACQUITY UPLC glycoprotein BEH amide 300 Å 1.7-&um;m column enables biopharmaceutical companies to better understand where glycan molecules are located within the therapeutic proteins they are developing. Identifying the precise location of glycans within a protein structure is essential to delivering safe and effective biotherapeutic proteins. The novel, patent-pending ACQUITY UPLC ethylene bridged hybrid (BEH) amide technology assists scientists in obtaining reproducible glycan-related chromatographic and mass spectrometry (MS) information at the intact protein, fragment, or peptide levels. Designed to be used with Waters ACQUITY UPLC systems, this new glycoprotein analysis column provides unprecedented resolution using MS-compatible hydrophilic interaction liquid chromatography (HILIC) separations. Laboratories can now resolve different glycoproteins and glycopeptides, determine where both N-linked and O-linked glycans are located within the protein, and better understand glycan modifications and patterns. Combining these capabilities with mass spectrometric analysis provides far greater information about glycoprotein structure than has been previously available.

mRNA Sequencing Preparation

A new high-throughput single-cell messenger RNA (mRNA) sequencing workflow for the C1 system enables large-scale studies to characterize heterogeneous samples. This validated workflow includes a new advanced integrated fluidic circuit (IFC) and reagent kit that significantly increases throughput and ease-of-use, while simultaneously decreasing the cost of preparation and sequencing (by maximizing sequencer capacity) on a per-cell basis. The C1 mRNA Seq HT application is the first and only commercial product to address large single-cell studies and is available today. This new offering is a complete solution that enables scientists to deeply explore the diversity of cell subpopulations, quickly discover novel or rare cell types, and increase the statistical sample size to better estimate biological variation between similar cell types. The C1 mRNA Seq HT IFC can capture up to 800 cells at a time, and employs a new protocol to facilitate two runs (or 1600 cells) a day.

Automated Colony Counter

The automated colony counter has now been improved. The industry-standard Scan range of counters have added a number of new features on all three models: the Scan 300, 500, and 1200. The level of automatic control has been increased, giving the user greater comfort. Now you can customize as many parameters as you want, eliminating the complicated batch settings and user input needed by other automated colony counters. The Scan 300, 500, and 1200 series are designed and built with the user in mind, and are compatible with the complete range of processes available in today's laboratory. They work seamlessly with spiral platers and are compatible with DataLink traceability systems and robotic analysis chains. An upgrade to the image resolution of up to 1 megapixel brings enhanced imaging. It is now possible to count as low as 0.05 mm and obtain clear colony separation.

Reference Standards

A unique range of genetically defined, highly characterized HDx reference standards for immunohistochemistry (IHC) assays is now available. The introduction of IHC HDx reference standards provides histopathology laboratories with a consistent and reproducible source of reference material for the development and quality control of IHC assays. The independent external controls contain precisely defined protein expression levels presented on one slide, allowing scientists to easily determine the sensitivity of their assay. These standards are unique in having undergone a high level of characterization at a molecular and protein level, including quantitative digital pathology (QDP), to quantify the intensity of staining. The use of independent external controls enables consistency, reproducibility, and accuracy to be maintained and monitored across the laboratory workflow. IHC HDx reference standards are presented as formalin-fixed paraffin-embedded (FFPE) cell lines on slides arranged for particular target tumor types. Alongside every positive core there is also a negative protein expressing cell line core.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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