DNA Repair

A membrane scaffold for repairing DNA

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Science  06 Nov 2015:
Vol. 350, Issue 6261, pp. 647-648
DOI: 10.1126/science.350.6261.647-d

Many cellular processes inadvertently cause DNA damage, so cell survival critically depends on high-fidelity DNA repair. In Escherichia coli, the protein RecA plays a central role in repairing damaged DNA. RecA forms filaments on the ends of broken DNA, which allow the DNA repair machinery to search the genome for homologous sequences for accurate repair of the DNA break. Rajendram et al. now show that RecA interacts with specific lipids in the inner plasma membrane of E. coli. This membrane scaffolding acts to store RecA in the absence of DNA breaks. It also helps to nucleate and stabilize RecA filament bundles when breaks form, promoting DNA repair.

Mol. Cell. 10.1016/j.molcel.2015.09.009 (2015).

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