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Science  20 Nov 2015:
Vol. 350, Issue 6263, pp. 991
DOI: 10.1126/science.350.6263.991-a

cellFRAP Imaging Platform

Enabling the easy addition of photomanipulation techniques to imaging platforms, Olympus has launched a new cellFRAP deck system for the popular "open source concept" IX83 and IX73 microscopes. The Olympus cellFRAP provides highly accurate and flexible live-cell photomanipulation with various evaluation options for data presentation needs. Unlike conventional widefield-based fluorescence recovery after photobleaching (FRAP) systems, the Olympus cellFRAP employs a diffraction-limited laser spot for high-intensity and precise positioning of the bleaching region across the full field of view (FOV). This ensures that photomanipulation reaches every point in the FOV without needing to move the sample. The system's excellent spot quality allows full flexibility in position and shape of the bleaching region, and enables control of the bleaching area with extreme accuracy. Driven by the Olympus real-time controller, the cellFRAP system achieves an unrivaled short switchover time of only 200 µs between bleach and postbleach acquisition, ensuring detection of the most valuable initial sample response after stimulation.

Linear Motor Microscope Stages

The HLD117 series of linear stages for inverted research microscopes sets new standards for convenience and top performance. The HLD117 linear stages operate on a different principle from conventional stepper motor, ball-screw based motorized stages. The HLD117 linear stage motor floats over a magnetic track, driving the x- and y- stage plates over precision bearing guides, providing near frictionless, ultrasmooth movement. This method of movement allows a wide range of scanning speeds (1 µm/sec up to 300 mm/sec) to be achieved, making these stages suitable for a vast range of applications from rapid screening to detailed imaging. Superb repeatability (±1.15 µm), high resolution (±0.05 µm), and exceptional accuracy (0.045 µm/mm of travel) along with 50 nm encoders as standard, make the HLD117 an excellent choice for advanced imaging techniques. Built for performance with unmatched acceleration rates and speeds, the HLD117 provides constant speeds with extremely low velocity ripple.

TERS Instrumentation

Tip-enhanced Raman scattering (TERS) is a technique that provides molecular information on the nanometer scale through the combination of a Raman spectrometer and a scanning probe microscope. TERS has been hampered by extremely long acquisition times (measured in hours) required for collection of reasonable pixel density, and is seen by the research community as a difficult tool. Horiba Scientific and AIST-NT now offer a solution that addresses all the instrumentation concerns and bring TERS as an analytical method to a completely new level. The XploRA Nano platform in the upright and side configuration, in combination with AIST-NT's SmartSPM and Horiba's XploRA spectrometer, offers a very compact (complete setup stands on a 900 × 760 × 55 mm optical table), fully integrated, and automated solution. The Horiba Scientific TERS instrumentation is robust, compact, and easy to use. It is currently available for chemical imaging at the nanoscale level for real-

Scanning Electron Microscope

A new variant of the world's fastest scanning electron microscope is now available: The Zeiss MultiSEM 506 features 91 beams working in parallel and increases the throughput of the Zeiss sMultiSEM 505 by a factor of three. The unrivaled net acquisition speed of more than 2 terapixels per hour enables large-scale experiments such as the imaging of cubic millimeters of brain tissue at nanometer resolution for the analysis of neural circuits. For research work conducted as part of numerous brain initiatives, this will speed up the ability to map whole areas of the brain to help understand the neuronal network. The MultiSEM 506 also demonstrates that the Zeiss multibeam technology is scalable and will satisfy future throughput needs in other fields as well, for example in semiconductor applications. The Zeiss MultiSEM 505 and 506 are designed for continual operation and fitted with the intuitive Zeiss Efficient Navigation (ZEN) software.

Atomic Force Microscope

The Keysight 9500 atomic force microscope (AFM) system seamlessly integrates new software, a new high-bandwidth digital controller, and a state-of-the-art mechanical design to provide unrivaled scan rates of up to 2 sec/frame (256 × 256 pixels). The ultrafast scan rates of the 9500 are made possible by Keysight's new Quick Scan technology. Available as a system option, Quick Scan is controlled through NanoNavigator, a powerful new imaging and analysis software package from Keysight. In addition to supporting Quick Scan functionality, NanoNavigator software lets researchers save time by using the new Auto Drive feature, which automatically and optimally sets all parameters for the 9500. AFM novices and experts alike can appreciate NanoNavigator's efficient, workflow-based graphical user interface, as it guides users step-by-step through system setup and operation via intuitive, eye-catching visuals. For ultimate convenience, the NanoNavigator mobile app for smartphones and tablets allows remote monitoring of AFM experiments while they are being performed by the 9500.

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