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Science  27 Nov 2015:
Vol. 350, Issue 6264, pp. 1108
DOI: 10.1126/science.350.6264.1108-a

Liquid Chromatograph System

The new ACQUITY Arc System is a quaternary liquid chromatograph that gives analytical laboratories running established liquid chromatography (LC) methods a clear choice for replicating or improving their separations performance. The system is specifically engineered to respond to the needs of analytical scientists for a single LC platform that can enable them to efficiently transfer, adjust, or improve their methods regardless of the LC platform on which they were developed. To date, scientists working with established methods haven't had an LC platform versatile enough to bridge the gap between high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC). With the introduction of the ACQUITY Arc System and its enabling Arc Multi-flow path technology, scientists now have the ability to emulate the gradient dwell volume and mixing behavior of various LC systems. When the appropriate fluidic path is selected, the ACQUITY Arc System can easily emulate a variety of HPLC systems without altering the method's gradient table, or provide UHPLC performance with the flip of a switch.

Protein Analysis Kits

A new tool for protein digestion is designed to substantially reduce preparation times and associated errors, facilitating fast, reliable analytical results. Current protein digestion techniques comprise complex procedures requiring determination of protein concentration followed by sample reduction and alkylation prior to digestion with trypsin. To improve this operation, the SMART Digest kit uses a simple three-step, easy-to-implement process that can be automated. Its immobilized trypsin design is formulated for high-quality data with a significantly reduced sample preparation time compared to traditional in-solution digestion methods. The increased reproducibility of digestion possible with this kit should enable users to implement generic, rapid, and robust methods for high-throughput processing of samples. Furthermore, the SMART Digest kit is designed to provide higher sequence coverage while reducing both chemically induced posttranslational modifications and the number of chemicals in the final sample.

SPE Columns

New polymer-based solid phase extraction (SPE) columns have been added to the tried and tested EVOLUTE EXPRESS line. EVOLUTE EXPRESS is a novel family of plates, and now columns, that simplify polymer-based SPE by employing a streamlined three-step protocol: load-wash-elute. By using this approach and removing the conditioning and equilibration steps necessary with traditional bioanalytical SPE procedures, processing and method development times are dramatically reduced without loss of analyte recovery or method robustness. The EVOLUTE EXPRESS design provides a uniform flow in the processing of aqueous samples and eliminates the need for reruns due to clogging. This clear-flow technology makes EVOLUTE EXPRESS particularly efficient and effective when used with SPE automated systems (such as the Biotage Extrahera), and enables consistent, rapid, and reliable manual processing. EVOLUTE EXPRESS columns are packed with polymer-based EVOLUTE chemistries (ABN, CX, WCX, AX, and WAX) to address most application needs in a wide range of laboratories.

Biomarker Services

Our new Biomarker Services include biomarker screening and assay development services, providing the customer a clear path from early discovery and exploratory studies to validated products. Following biomarker identification, the assays are easily transferred to a customer's own lab or a contract research organization (CRO) to continue validation studies, allowing for consistency across the entire study. This ensures the reproducibility and accuracy of results and speeds up the biomarker research cycle. These biomarker services leverage Meso Scale Diagnostic's Multi-Array technology, which has been widely adopted by researchers worldwide due to its high sensitivity, excellent reproducibility, and wide dynamic range. By utilizing the U-PLEX, V-PLEX, and S-PLEX platforms, each custom service can deliver rapid multiplex development, rigorous assay validation, and ultimate sensitivity to measure previously unmeasurable biomarkers, depending on user requirements. With the addition of over 80 human, mouse, and nonhuman primate assays, the U-PLEX platform will continue to help customers quickly and easily design and build personalized multiplex assays.

Single-Cell T-Cell Receptor Assay

The single cell T-cell receptor (TCR) panel for Precise assays enables a fast, simple, and high-throughput method for sequencing thousands of single cells. It is the first commercial assay to enable the sequencing of the alpha and beta chain within the same cell, 96 or 384 cells at a time. The TCR panel may be combined with other standard or custom gene expression panels to enable the correlation of TCR sequences to function in individual T cells. Based on patented Molecular Indexing technology, the Precise assays offer absolute quantization and bias-free expression information. The assays allow the examination of large numbers of standard or low-input messenger RNA (mRNA) samples from precious samples or whenever absolute quantitation is required. The Precise assays combine molecular and sample indexing in 96- and 384-sample formats, enabling customers to sequence up to 4,608 samples on one sequencing run without investment in new equipment or extensive training.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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